Randomization (2) 0 if no randomization performed or not mentioned, 1 if partial or inadequate, 2 if adequate |
Placebo (2) 0 if no placebo, 1 if inert placebo, 2 if compared to gold standard. |
Blinding (2) 0 No blinding, 1 Single blinded, 2 Double blinded |
Objective measurement (1) Example: 1 if Colorimeter is used for melasma and 0 if MASI is used. |
Sample size more than 21 (1) Effect size of 0.5, alpha 0.05 and power 80 |
Sample selection and allocation concealment (1) 0 if study is done on clinic staff or if person knows allocated group. 1 if appropriate. |
Economical (1) 1 if intervention cheaper than gold standard |
Conflict of interest (1) 0 if present, 1 if absent |
Withdrawal / Dropouts (1) 0 if more than 1 in 5 (20%) or not mentioned, 1 if not |
Coherent endpoints & assessment times (1) 0 if not mentioned or inappropriate, 1 if appropriate |
Co-Interventions (1) 0 if multiple active ingredients tested, 1 if single |
Acceptable theory (1) 0 if no rational theoretical basis, 1 if sound |
If a criteria is not mentioned in the publication, the criteria is not scored and gets 0 |
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